258 Seasonal variation, climate factors and squamous cell carcinoma

The impact of climate factors on the seasonality squamous cell carcinoma (SCC) diagnoses is not well understood. We identified 1061 SCC patients (median age=78) in Rhode Island, a state with four distinct seasons, from 2017-2019. Due to known effects organ transplants and indoor tanning development, past medical history either were excluded; recurrent cases also included. Dates 1338 996 collected calculate proportion per month. Relationships between average monthly values 2017-2019 evaluated Spearman’s rank-order correlations. Climate included UV index, ambient temperature, humidity, cloudiness, air pressure, number days sun, hours sunlight, volume precipitation. Our results show that rose beginning February peaked May, consistent levels throughout mid-summer late fall (July-November). There significant positive correlations (p<0.05) sun month diagnosis (r=0.77) prior (r=0.75) diagnosis. Other weather these months, including temperature significantly positively correlated When analyzed separately, high UV-exposed sites, head neck distal extremities (n=1031), showed similar correlation same (r=0.71) following (r=0.66). was slight delay influence low body trunk proximal extremities, (n=307); while correlated, variable at one two months (r=0.83) frequency. These suggest have seasonal variation some variables, particularly may play role patterns SCC.